The following is a list of peer review articles that contain the abstracts from professional Scientific Journals found on PubMed. 

This is a small sampling of research performed on L-Arginine and Nitric Oxide.

Click on any one of the links below to access the study or article.

Dr. Ignarro receives Prestigious Awards for his work on NO

Dr. Prendergast speaks out on his Experience with L-Arginine & Various Studies

Therapeutic Interventions in Endothelial Dysfunction:  Endothelium as a Target Organ, 
Summary          Full

Long-Term L-Arginine Supplementation Improves Small-Vessel Coronary Endothelial Function in Humans,
Full

Arginine Metabolism: Enzymology, Nutrition, and Clinical Significance:  Arginine and Endothelial and Vascular Health,
Abstract           Full

Session V: Therapeutic Strategies and Supplementation Discussion Summary,
Full

Recent Advances on the Roles of NO in Cancer and Chronic Inflammatory Disorders

Oral l-arginine supplementation improves endothelial function and ameliorates insulin sensitivity and inflammation in cardiopathic nondiabetic patients after an aortocoronary bypass

Aged garlic extract supplemented with B vitamins, folic acid and l-arginine retards the progression of subclinical atherosclerosis: A randomized clinical trial

Anorexia nervosa: A role for L-arginine supplementation in cardiovascular risk factors?

Nitric Oxide as an Initiator of Brain Lesions During the Development of Alzheimer Disease.

Effects of neuronal nitric oxide synthase on human coronary artery diameter and blood flow in vivo.

Anti-hypertensive nutraceuticals and functional foods

Nitric oxide and vascular insulin resistance

Early prevention by L-Arginine attenuates coronary atherosclerosis in a model of hypercholesterolemic animals; no positive results for treatment.

The impact of oral L-arginine supplementation on acute smoking-induced endothelial injury and arterial performance

Nitric Oxide, NAD(P)H Oxidase and Atherosclerosis.

Novel risk factors for cardiovascular disease and tobacco smoke

From arginine methylation to ADMA: a novel mechanism with therapeutic potential in chronic lung diseases.

Effect of L- arginine on electrocardiographic changes induced by hypercholesterolemia and isoproterenol in rabbits.

Participation of nitric oxide in different models of experimental hypertension.

The role of the L-arginine-nitric oxide pathway in preeclampsia.

Variation in L-arginine intake follow demographics and lifestyle factors that may impact cardiovascular disease risk.

Increase in fasting vascular endothelial function after short-term oral L-arginine is effective when baseline flow-mediated dilation is low: a meta-analysis of randomized controlled trials.

Beneficial effects of autologous bone marrow cell infusion and antioxidants/L-arginine in patients with chronic critical limb ischemia.

Arginine metabolism and nutrition in growth, health and disease.

Inducible nitric oxide synthase is involved in endothelial dysfunction of mesenteric small arteries from hypothyroid rats.

L-arginine analogs--inactive markers or active agents in atherogenesis?

Endogenous nitric oxide synthase inhibitors, arterial hemodynamics, and subclinical vascular disease: the PREVENCION Study.

L-arginine inhibits isoproterenol-induced cardiac hypertrophy through nitric oxide and polyamine pathways.

Nitric oxide modulates the cardiovascular effects elicited by acetylcholine in the NTS of awake rats.

L-arginine ameliorates experimental autoimmune myocarditis by maintaining extracellular matrix and reducing cytotoxic activity of lymphocytes.

Asymmetric dimethylarginine (ADMA) and other endogenous nitric oxide synthase (NOS) inhibitors as an important cause of vascular insulin resistance.

Nebivolol: a highly selective beta1-adrenergic receptor blocker that causes vasodilation by increasing nitric oxide.

Neurally-derived nitric oxide regulates vascular tone in pulmonary and cutaneous arteries of the toad, Bufo marinus.

Effects of nitric oxide and superoxide on relaxation in human artery and vein.

The impact of oral L-arginine supplementation on acute smoking-induced endothelial injury and arterial performance.

Effect of L-arginine on circulating endothelial progenitor cells in hypercholesterolemic rabbits.

Participation of nitric oxide in different models of experimental hypertension.

Roles of oxidants, nitric oxide, and asymmetric dimethylarginine in endothelial function.

L-arginine analogs--inactive markers or active agents in atherogenesis?

Protective effects of L-arginine against ischemia-reperfusion injury in non-heart beating rat liver graft.

[Endothelium and nitric oxide]

L-Arginine prevents metabolic effects of high glucose in diabetic mice.

Inducible nitric oxide synthase activity is increased in patients with rheumatoid arthritis and contributes to endothelial dysfunction.

Depression and cardiovascular disease: role of nitric oxid.

L-arginine protects from pringle manoeuvere of ischemia-reperfusion induced liver injury

Effects of long-term losartan and L-arginine treatment on haemodynamics, glomerular filtration, and SOD activity in spontaneously hypertensive rats.

L-arginine preferentially dilates stenotic segments of coronary arteries thereby increasing coronary flow

[L-arginine pretreatment lowers cerebral metabolism for cerebral protection during deep hypothermic circulatory arrest]

Effect of long term oral administration of L-arginine on experimentally produced myocardial ischemia in rabbits

L-Arginine therapy in cardiovascular pathologies: beneficial or dangerous?

The endothelium as a target in renal diseases.

Pycnogenol, French maritime pine bark extract, augments endothelium-dependent vasodilation in humans

Role of nitric oxide deficiency in the development of hypertension in hydronephrotic animals

Inhibitory effects of endogenous L-arginine analogues on nitric oxide synthesis in platelets: role in platelet hyperaggregability in

Inhibitory effects of endogenous L-arginine analogues on nitric oxide synthesis in platelets: role in platelet hyperaggregability in hypertension.

Impaired nitric oxide bioavailability and L-arginine reversible endothelial dysfunction in adults with falciparum malaria.

Endogenous nitric oxide attenuates neutrally mediated cutaneous vasoconstriction.

Induction of insulin secretion in engineered liver cells by nitric oxide

Nitric oxide deficiency in chronic kidney disease

Asymmetric dimethylarginine plasma concentrations and L-arginine/asymmetric dimethylarginine ratio in patients with slow coronary flow.

Plasma asymmetric dimethylarginine and L-arginine levels in patients with cardiac syndrome X.

Intracarotid L-arginine reverses motor evoked potential changes in experimental cerebral vasospasm.

L-arginine transporters in cardiovascular disease: a novel therapeutic target

Effect of inhibition of neuronal nitric oxide synthase and L-arginine supplementation on renal ischaemia-reperfusion injury and the renal nitric oxide system

Concomitant treatment with oral L-arginine improves the efficacy of surgical angiogenesis in patients with severe diffuse coronary artery disease: the Endothelial Modulation in Angiogenic Therapy randomized controlled trial

Role of nitric oxide in inflammatory diseases

Obesity reduces the bioavailability of nitric oxide in juveniles

Nitric oxide synthesis blockade increases hypertrophy and cardiac fibrosis in rats submitted to aerobic training.

Clinical use of nitric oxide donors and L-arginine in obstetrics

Whole body nitric oxide production is not decreased in patients with coronary atherosclerosis but is inversely related to plasma homocysteine

L-arginine infusion decreases plasma total homocysteine concentrations through increased nitric oxide production and decreased oxidative status in Type II diabetic patients

Decreased whole body endogenous nitric oxide production in patients with primary pulmonary hypertension.

Conservation of whole body nitric oxide metabolism in human alcoholic liver disease: implications for nitric oxide production

Basal nitric oxide synthesis in essential hypertension

Nitric oxide and hypertension in 1995

Neurobiology of nitric oxide

Nitric oxide in health and disease of the nervous system

Endogenous nitric oxide synthesis: biological functions and pathophysiology

Vascular endothelium and nitric oxide in childhood hypertension

Clinical significance of nitric oxide in hypertension]

Nitric oxide, L-arginine and the kidney. Experimental studies of new therapy approaches]

The role of nitric oxide in hypertension and renal disease progression

Nitric oxide, L-arginine and the kidney. Experimental studies of new therapy approaches]

Role of endogenous nitric oxide in circadian blood pressure regulation in healthy humans and in patients with hypertension or atherosclerosis.

Circulating nitric oxide (NO), asymmetric dimethylarginine (ADMA), homocysteine, and oxidative status in obstructive sleep apnea-hypopnea syndrome (OSAHS).

Metabolic effects of a novel silicate inositol complex of the nitric oxide precursor arginine in the obese insulin-resistant JCR:LA-cp rat.

Therapeutic potential of nitric oxide donors in the prevention and treatment of atherosclerosis

Endothelium and nitric oxide

Coronary endothelial vasodilator dysfunction: clinical relevance and therapeutic implications

Cutaneous neuronal nitric oxide is specifically decreased in postural tachycardia syndrome

Apoptosis signal-regulating kinase-1 is involved in vascular endothelial and cardiac remodeling caused by nitric oxide deficiency


Exercise training reduces severity of atherosclerosis in apolipoprotein E knockout mice via nitric oxide

Asymmetric dimethylarginine (ADMA) in vascular, renal and hepatic disease and the regulatory role of L-arginine on its metabolism

Asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, explains the "L-arginine paradox" and acts as a novel cardiovascular risk factor

The prophylactic effect of L-arginine in acute ischaemic colitis in a rat model of ischaemia/reperfusion injury

 The L-arginine paradox: Importance of the L-arginine/asymmetrical dimethylarginine ratio

Mechanisms of disease: L-arginine in coronary atherosclerosis--a clinical perspective.

L-Arginine in coronary atherosclerosis

Effects of L-arginine on the endogenous angiogenic response in a model of hypercholesterolemia

L-arginine in cardiovascular disease: dream or reality?

L-Arginine, the substrate for NO synthesis: an alternative treatment for premature atherosclerosis?

L-Arginine: rediscovery in progress

Arginine nutrition and cardiovascular function